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The effects of green tea extract

Angiogenesis, the process by which new blood vessels are formed by splitting or sprouting from pre-existing ones, occurs in several physiologic and pathologic situations. Angiogenesis-associated disorders include tumor growth and metastasis, ischemic disease, diabetes, rheumatoid arthritis, atherosclerosis, inflammatory processes, and infectious processes.1 Therefore, the modulation of angiogenesis, either by promoting therapeutic angiogenesis or by preventing pathologic angiogenesis, is an exciting prospect for modern medicine.

Angiogenesis is a complex physiologic process consisting of several distinct steps. It begins with the local degradation of the basement membrane surrounding capillaries. The endothelial cells (ECs) then migrate toward angiogenic stimuli and proliferate. Finally, the ECs undergo morphogenesis, leading to the formation of a 3-dimensional capillary network. It has long been recognized that the activation of angiogenesis is associated with a number of distinct phenotypic changes in ECs that enable them to enter an angiogenic cascade.2