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Neurobiology of Disease.

  • The use of isolated parenchymal and non-parenchymal cells of the liver including hepatocytes, stellate cells, Kupffer cells, endothelial cells, cholangiocytes and resident lymphocytes particularly as they relate to the pathogenesis of liver disease.
  • Progenitor and stem cell therapies of genetic and acquired hepatobiliary diseases.
  • Mechanisms of bile formation, bile salt synthesis hepatic cholesterol and lipid metabolism and their genetic and molecular regulation of cholestatic and gallstone disease.
  • Molecular genetics and biochemical basis for NAFLD and NASH and approaches to intervention and reversal.
  • Physiologic mechanisms of hepatobiliary transport including mechanisms of uptake and excretion of organic solutes, heavy metals, and ions.
  • Inflammatory response of the liver to injury or infection, pro- and anti-inflammatory mediators, oxidative stress and ER stress, apoptosis and autophagy.
  • Mechanism of hepatocyte injury including immune response, oxidative stress, apoptosis, pro- and anti-inflammatory mediators, including signal transduction pathways and neuromediators.