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innovative research in the cancer biology field

The Moskofidis laboratory has been conducting basic research in microbial (viral) pathogenesis and immunology/inflammation, as well as in protein homeostasis and molecular chaperone biology. In addition to elucidating basic mechanisms of viral pathogenesis, a major focus of the Moskofidis laboratory is on the mechanisms of chaperone-mediated cancer promotion. These are areas of great medical importance, and there is reasonable expectation that this research will continue to provide the rationale to develop novel strategies to prevent, and perhaps more effectively treat, viral infectious diseases, and cancer. One approach has focused on studying the function of these molecules in different cancer types (liver, breast and lung) using transgenic (knockout) mice and novel cancer mouse models developed by applying the CRISPR/Cas9 editing approach. Specifically, in the Moskofidis laboratory, the development and functional analyses of several conditional knockout mouse models – including the major members of HSP70 and HSP90 in the endoplasmic reticulum (GRP78, GRP170, SIL1, GRP94), cytoplasm (HSP70, HSC70, HSP25), and mitochondrion (GRP75) – provides important materials for innovative research in the cancer biology field