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inflammation in cancer initiation and progression.

The Horuzsko Laboratory studies the role of inflammation in cancer initiation and progression. Studies on various mouse cancer models using deletion of the proinflammatory TREM-1 gene, an amplifier of inflammatory response, have shown a remarkable decrease of tumor initiation and cancer development. Dr. Horuzsko’s group observed that TREM1 plays a critical role in the crosstalk between Kupffer cells and hepatocytes during liver injury and tumorigenesis (J Enzymol Metab. 2015, 1(1).pii: 101). The Horuzsko Laboratory research interest also addresses the pathogenesis of tissue fibrosis, primarily using the liver as a model where TREM1was shown to play a critical role for macrophages in promoting the development of liver fibrosis. In collaboration with Dr. L. Mulloy at the MCG Department of Medicine, the Horuzsko Laboratory has studied the role of HLA-G in prolongation of kidney allograft survival. They demonstrated the mechanisms that B cells are reprogrammed by HLA-G and their signatures in kidney transplant patients (Tissue Antigens, 2015). Dr. Horuzsko’s group is focusing on the investigation of the effects of different HLA-G molecules on modulation of the function of immune cells using NOD (non-obese diabetic) scid (severe combined immunodeficiency) gamma (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ) NSG humanized models. They also developed methods and humanized models to control human allograft rejection using classical and modified immunosuppressive therapies. This will allow clinicians to optimize and immunologically “personalize” the treatment of allograft rejection.