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Inflammation and Wound Healing”

Chemical mediators of inflammation  Chemical mediators originate either from the plasma or from cells (neutrophils, macrophages, lymphocytes, basophiles, mast cells and platelets).  Some of the chemical mediators of inflammation include histamine, serotonin, lysosomal enzymes, prostaglandins, leukotriens, activated oxygen species, nitric oxide, cytokines,  Mediators of the inflammatory response are presented in (see table2.2 Table 2.2. Mediators of Inflammation MEDIATION SOURCE MECHANISM OF ACTION Pathophysiology 32 Histamine Serotonin K i n i n s (bradykinin) C o m p l e m e n t Components (C3a, C4a, C5a) Fibrinopeptides Prostaglandins a n d Leukoterienes Stored in granules of basophils, mast cells, platelets Stored in platelates, mast cells, enterochromaffin cells of GI tract Produced from precursor factor kininogen as a result of activation of Hageman factors (XII) of clotting system A n a p h y l a x i s a g e n t s g e n e r a t e d f r o m complement pathway activation Produced from activation of the clotting system P r o d u c e d f r o m Arachidonic acid Causes vasodilation & i n c r e a s e d v a s c u l a r p