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The formation of crystals in the tubular fluid

In vitro gel analysis to study chelation effect

In order to re-confirm the inhibitory effect of STS on calcium oxalate crystal, we performed an in-vitro analysis. The calcium oxalate crystals that have been produced in this study were similar to the crystals in the urine of patients with calcium oxalate crystals. The crystals were predominantly of monohydrate type, confirmed by FTIR. According to Figure-2, STS showed a dose-dependent inhibition of calcium oxalate stone formation. Apparently, only 18% direct inhibition was shown with maximum STS concentration of 200mM, indicating an additional tissue based mechanism for its renal protective action.

Figure 2 Images of agar gel slides and graph representing the percentage inhibition produced by STS in calcium oxalate crystal formation represented as a streak.