Email: support@essaywriterpros.com
Call Us: US - +1 845 478 5244 | UK - +44 20 7193 7850 | AUS - +61 2 8005 4826

supersaturated urine form microscopic crystalline structures

Histopathological analysis of renal tissues in the control group showed no calcium oxalate deposits or other abnormalities in different segments of the nephron. But in the urolithiasis induction group, a substantial amount of calcium oxalate deposition was observed, and this was present in whole parts of three major areas of the kidney . Renal tubular dilations with tubular basophilic and epithelial damage were also observed on pathological examination. In sodium thiosulfate treated group the number of calcium oxalate deposits was significantly lower than that in the disease control group with only mild nephropathy in one of the animals in that group Rats treated with diazoxide alone showed less obstructive damage while glibenclamide treated rats showed severe damage and obstruction (F Apparently more renal damage, inflammation and hemolysis were observed in rats co-administered with STS and diazoxidwhile STS administration along with glibenclamide showed preserved renal tissue with mild obstruction

Figure 1 Light microscopic architecture of kidney showing (A) Renal tissue of control (group 1) rats showing no sign of crystal deposition. (B) Renal tissue of urolithiatic rats (group 2) showing crystals deposition and severe obstructive nephropathy (C) Renal tissue of (group 3) STS treated rats showing mild crystal deposition with mild nephropathy. (D) Renal tissue of (group 4) diazoxide treated rats showing mild crystal deposition with moderate obstructive nephropathy (E) Renal tissue of (group 5) glibenclamide treated rats showing prominent crystal deposition with severe obstructive nephropathy (f) Renal tissue of (group 6) diazoxide +STS treated rats showing crystal deposition with severe obstructive nephropathy (g) Renal tissue of (group 7) glibenclamide + STS pretreated rats low crystal deposition with mild nephropathy (h) Crystal’s deposition as observed under 40X zoom.