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Skin and mucus membrane

Hashimato’s thyroiditis is predominantly a disease of women.
The course of the disease varies. At the onset only a goiter
may be present. In time, hyprothyroidism usually become
evident. Although the disorder generally causes
hypothyroidism, a hyperthyroid state may develop mid course
in the disease. The transient hyperthyroid state is due to
leakage of performed thyroid hormone from damaged cells of
the gland.
Myxedema affects almost all of the organ systems in the body.
The manifestations of the disorder are largely related to two
factors.

  1. The hypometabolic state resulting from thyroid
    hormone deficiency and
  2. Myxedematous involvement of body tissues.
    Pathophysiology
    175
    Although the myxedema is most obvious in the face and other
    superficial parts, it also affects many of the body organs and is
    responsible for many of the manifestations of the hypothyroid
    state.
    The hypometabolic state associated with myxedema is
    characterized by a gradual onset of weakness and fatigue, a
    tendency to gain weight despite a loss in appetite, and cold
    intolerance. As the condition progresses, the skin becomes
    dry and rough and acquires a pale yellowish cast, which is due
    primarily to carotene deposition, and the hair becomes coarse
    and brittle. There is loss of the lateral one-third of the
    eyebrows. Gastrointestinal motility is decreased, giving rise to
    constipation, flatulence, and abdominal distention. Nervous
    system involvement is manifested in mental dullness, lethargy,
    and impaired memory