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Primary immune deficiency diseases

The mechanism of action of bisphosphonate drugs means that they impair bone healing and modeling, which in turn leads to increased risk of jaw osteonecrosis following surgical dental procedures. Oral infection increases the risk of patients developing this condition. Regarding diabetes in particular, several published papers have demonstrated how control of periodontal health may be useful in managing the general health of patients. There are also correlations observed between changes in oral inflammatory cytokines and cardiovascular risk. Oncological pathologies, which are often accompanied by a pattern of alterations in gene expression, have also been reported to exhibit oral manifestations with alteration of the oral mucosa. Moreover, these pathologies can be located both at the oral cavity and in other nonoral areas of the body, and for this reason the first dental visit is crucial to achieve early diagnosis.

This special issue aims to highlight the close relationship between systemic disease and oral pathologies, and to investigate the connection between alterations in the oral immunological profile and systemic disease. Researchers are invited to submit original research articles and review articles in this field, with a focus on profiles of oral inflammatory cytokines and gene expression related to systemic and local pathologies. Submissions concerning acute, chronic, and oncological conditions are all welcomed. In order to cover state-of-the-art research and understanding in all relevant disciplines, submissions covering anatomical, histological, and biological features of the oral immunological profile of systemic