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Life long hormone replacement

Hashimato’s thyroiditis is predominantly a disease of women. The course of the disease varies. At the onset only a goiter may be present. In time, hyprothyroidism usually become evident. Although the disorder generally causes hypothyroidism, a hyperthyroid state may develop mid course in the disease. The transient hyperthyroid state is due to leakage of performed thyroid hormone from damaged cells of the gland. Myxedema affects almost all of the organ systems in the body. The manifestations of the disorder are largely related to two factors. 1. The hypometabolic state resulting from thyroid hormone deficiency and 2. Myxedematous involvement of body tissues. Pathophysiology 175 Although the myxedema is most obvious in the face and other superficial parts, it also affects many of the body organs and is responsible for many of the manifestations of the hypothyroid state. The hypometabolic state associated with myxedema is characterized by a gradual onset of weakness and fatigue, a tendency to gain weight despite a loss in appetite, and cold intolerance. As the condition progresses, the skin becomes dry and rough and acquires a pale yellowish cast, which is due primarily to carotene deposition, and the hair becomes coarse and brittle. There is loss of the lateral one-third of the eyebrows. Gastrointestinal motility is decreased, giving rise to constipation, flatulence, and abdominal distention. Nervous system involvement is manifested in mental dullness, lethargy, and impaired memory.