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Hypersensitivity reaction

Alteration in thyroid function An alteration in thyroid function can represent either a hypo functional or hyper functional state. The manifestations of these two altered states are summarized below. Table 6.1 Manifestations of hypothyroid and hyperthyroid states Pathophysiology 170 Level of organization Hypo state Hyper state Basal metabolic rate Decreased Increased Sensitivity to catecholamines Decreased Increased General features Myxedematous feutures keep voice impaired growth (child Exophthalmos lid lag decreased blinking Blood cholesterol levels general behavior Increased mental retardation (Infant) Mental & physical sluggishness somnolence Restlessness, irritability anxiety hyperkinesis wakefulness Cardiovascular function Decreased cardiac output Brady cardia Increased cardiac out put tachycardia and palpitations Gastro intestinal function Constipation decreased appetite Diarrhea increased appetite Respiratory function Hypoventilation Dyspnea Muscle tone and reflexes Decreased Increased, with t r e m o r a n d fibrillatory twitching Temperature tolerance Cold intolerance Heat intolerance Pathophysiology 171 Skin and hair D e c r e a s e d sweating coarse and dry skin and hair Increased sweating thin and silky skin and hair Weight Gain Loss Disorders of the thyroid