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Expression of Complex Diseases Like Alzheimer’s

Thalidomide inhibits angiogenesis. The next crucial discovery that uncovered the clinical potential of thalidomide came in 1994, when thalidomide was found to inhibit angiogenesis — the formation of new blood vessels, which is a crucial process in the growth and metastasis of solid tumours. Judah Folkman was one of the first researchers to associate angiogenesis with tumour development in the early 1970s and it was from his laboratory that the inhibitory effect of thalidomide on angiogenesis was demonstrated. He believed that the classical congenital defects that are caused by thalidomide treatment — abnormal limb development — were caused by the inhibition of blood-vessel growth in the developing fetal limb bud. Using a rabbit cornea micropocket assay, it was demonstrated that thalidomide could, in fact, inhibit basic fibroblast growth factor (bFGF)-induced angiogenesis21. However, despite this study, it is worth noting that the link between the teratogenic properties of thalidomide and its anti-angiogenic activity