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cells expressing homozygous

SRF is a highly conserved, ubiquitously expressed, and multifunctional founding member of the MADS (MCM1, Agamous, Deficiens, and SRF) box family of transcription factors, that has long been considered central to several regulatory complexes in muscle and non‐muscle cells [14]. SRF regulates the expression of many muscle‐specific and mitogen‐responsive genes including some of the hypertrophy markers such as atrial/brain natriuretic peptides (ANF/BNP), Myosin heavy chains and α‐skeletal/cardiac actin, through binding to single or multiple consensus CArG box (CC[A/T]2A[A/T]3GG) element in their promoter or enhancer sequences [15]. SRF in addition to affecting its target gene expression, also recruits different transcription factors in the heart, such as, cardiac NK2 Homeobox 5 (Nkx2.5), Transcriptional enhancer factor 1 (TEF‐1) , cardiac GATA family factors, and cofactors like myocardin, and of myocardin‐related transcription factors . SRF is therefore at the juncture of multiple signaling pathways that binds to serum response element in the promoter region of target genes and regulates the activity of many immediate‐early genes, thereby participating in cell cycle regulation, apoptosis, cell growth, and cell differentiation in other cell types, and cell growth and homeostasis in cardiomyocytes.