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acid in aqueous solution

Subchronic or Prechronic Exposure/ …The effects of nitrogen in the diet on ammonia detoxification /were studied/, using 210 rats and 6 diets containing 50, 150, and 700 g casein/kg (low-, optimal-, or high-protein diet, respectively), with or without the addition of ammonium chloride at 20 g/kg. After 8 or 9 days of feeding, the LD50 from an intraperitoneal injection of a 2.7% solution of ammonium chloride was determined. The LD50 increased in proportion to the amount of nitrogen in the diet. The data suggest that higher doses of exogenous ammonia were tolerated by rats on protein-rich diets or diets containing an ammonium salt as an additive. An adaptive capacity for ammonia detoxification was further demonstrated …in a study using rats fed low-protein diets with the addition of NH4Cl. The LD50 values for the ip injection of 2.7% NH4Cl were higher in animals fed low-protein diets supplemented with NH4Cl. …Weanling rats /were raised/ for 3-6 weeks on a protein-deficient diet. Subsequent challenge by a large, intraperitoneally-injected dose of ammonium chloride indicated that severe protein deprivation increased vulnerability to ammonia poisoning compared with that of control groups not prefed protein-deficient diets. Thus, with the exception of animals suffering from liver dysfunction, animals on high-protein diets seem able to tolerate a higher oral intake of an ammonium salt.